Giant cell granuloma (GCG) is an uncommon disease of unknown etiology and varying behavior. It is potentially destructive and affects mainly the facial region of the mandible. We discuss the best method of treatment, focusing on a low recurrence rate with the least aggressive techniques. Peripheral ostectomy with additional resection of the lesions may decrease the recurrence rate while minimizing the associated morbidity. Video-assisted surgery allows an accurate exploration of the operative field and complete removal of lesions in area difficult to access. We advocate the use of video-assisted peripheral ostectomy as described in the 2 cases of GCG of the maxilla and mandible.