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Year: 2001  Vol. 5   Num. 3  - July/Sept Print:
Original Article
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Efficacy and Safety of Oral Gatifloxacin in Patients with Acute Bacterial Sinusites
Estudo da Eficiência e Segurança da Gatifloxacina Oral em Pacientes com Sinusite Bacteriana Aguda
Author(s):
Ricardo Ferreira Bento*, Arthur Menino Castilho**.
Key words:
gatifloxacin, fluoroquinolone, acute bacterial sinusites, efficacy, safety.
Abstract:

Introduction: Gatifloxacin is a new broad-spectrum fluoroquinolone with excellent activity against prevalent respiratory bacteria, including penicillin-resistant Streptococcus pneumoniae and other atypical pathogens. Aim: The aim of this study was to evaluate the efficacy and safety of gatifloxacin in patients with acute bacterial sinusites. Material and method: In this multicenter, open label, prospective study, 2787 adult outpatients with the diagnosis of acute bacterial sinusites, were treated with gatifloxacin 400mg PO once a day, for 10 days. A standard report form was filled by an unpaid voluntary physician, who evaluated the patient, based on adverse events and efficacy criteria. Results: The global rate of cure and improvement was 96,2%. The incidence of relapse (0,6%) and therapeutic failure (1,1%) were low. Conclusions: Oral gatifloxacin, 400mg once a day, is effective and safe for patients with acute bacterial sinusites.

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