Title
Search
All Issues
15
Year: 2014  Vol. 18   Num. 1  - Jan/Mar
DOI: 10.1055/s-0033-1358659
Print:
Review Article
Versão em PDF PDF in English TextoText in English
Anatomical Changes and Audiological Profile in Branchio-oto-renal Syndrome: A Literature Review
Author(s):
Tâmara Andrade Lindau, Ana Cláudia Vieira Cardoso, Natalia Freitas Rossi, Célia Maria Giacheti
Key words:
branchio-oto-renal syndrome - BOR syndrome - hearing - review
Abstract:

Introduction: Branchio-oto-renal (BOR) syndrome is an autosomal-dominant genetic condition with high penetrance and variable expressivity, with an estimated prevalence of 1 in 40,000. Approximately 40% of the patients with the syndrome have mutations in the gene EYA1, located at chromosomal region 8q13.3, and 5% have mutations in the gene SIX5 in chromosome region 19q13. The phenotype of this syndrome is characterized by preauricular fistulas; structural malformations of the external, middle, and inner ears; branchial fistulas; renal disorders; cleft palate; and variable type and degree of hearing loss.

Aim: Hearing loss is part of BOR syndrome phenotype. The aim of this study was to present a literature review on the anatomical aspects and audiological profile of BOR syndrome.

Data Synthesis: Thirty-four studies were selected for analysis. Some aspects when specifying the phenotype of BOR syndrome are controversial, especially those issues related to the audiological profile in which there was variability on auditory standard, hearing loss progression, and type and degree of the hearing loss. Mixed loss was the most common type of hearing loss among the studies; however, there was no consensus among studies regarding the degree of the hearing loss.

  Print:

 

All right reserved. Prohibited the reproduction of papers
without previous authorization of FORL © 1997- 2019