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Year: 2007  Vol. 11   Num. 3  - July/Sept Print:
Original Article
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Epidemiologic Study of Squamous Cell Carcinoma of the Mouth and Oropharynx
Estudo Epidemiológico do Carcinoma Espinocelular da Boca e Orofaringe
Author(s):
Ricardo Salinas Perez1, Simone Marques de Freitas1, Rogério Aparecido Dedivitis2, Abrão Rapoport3, Odilon Victor Porto Denardin4, Josias de Andrade Sobrinho5
Key words:
Squamous cell carcinoma. Mouth. Oropharynx. Epidemiology.
Abstract:

Objective: To establish the relationship among demographic variables, clinico-pathological factors, habits, stage and prognostic of squamous cell carcinoma of the mouth and oropharynx. Patients and methods: retrospective observational study of 552 patients with squamous cell carcinoma of the mouth and oropharynx treated from 2000 to 2004. The variables studied were: gender, ethnics, age, smoking, alcohol consumption, stage and follow up. Results: There was a prevalence of men over females in a 5:1 ratio, whereas for ethnics there was a prevalence of Caucasians over the other ones in a 3:1 ratio. For the risk factors, the association of smoking and alcohol consumption was constant, mainly in patients with advanced stage (III and IV), demonstrating the connection between the carcinogens and these stages. Regarding the location, a clear prevalence of the inferior portion of the oral cavity was found, and only in the tongue the diagnosis was early. It was also highlighted that early diagnosis was not found in the oral cancer. The survival rate was 25.5%. At the end of the study an increase in cases of initial stage (stages I and II), and a decrease in advanced cases (III and IV) in the period between 2000 and 2004 was verified. Conclusion: There was a higher incidence of oral and oropharyngeal cancer in men, the carcinogens were present in all stages of the disease, the recurrence and the follow up interruption were the usual determinants of death and the advanced stages III and IV were prevalent.

INTRODUCTION

Malignant neoplasias of oral cavity is a serious issue for public health in Brazil and worldwide. According to the valuations of Instituto Nacional do Câncer do Ministério da Saúde (National Institute of Cancer - Health Ministry) done in 2004, oral cancer is the seventh most frequent malignant neoplasia in Brasil(1). There are many factors contributing for such increase. Aging originated from social-economic development prevents early deaths and allows the establishment of diagnosing programs for the disease, with improvement of population statistical controls. Therefore, urbanization and technological development expose people to diseases caused by food additives, pesticides, pollution, smoking and alcohol. These two last ones are responsible for the risk of an oral cancer in up to 140 times(1).

Cancer in Brazil is a rather worrying issue. The increase of occurrence of the disease and consequent death are at the top of the rank of the world. Besides, diagnosis, which can be easily done by finding neoplasm, is usually done when in advanced stages (III and IV), what can define the bad results of surviving this disease, independent on the therapy. There is also a lack of information in how to prevent oral and oropharynx cancer from both population and professionals, what determines delay of diagnosing and therapy(1).

Knowing the epidemiological behaviour of squamous cell carcinoma of the mouth and oropharynx allows a proper planning of preventive resources, diagnosing and therapy for it. The target of this study is to establish relation between demographical factors, clinical-pathological period, staging and follow-up of the disease.


PATIENTS AND METHODS

This study presents retrospective epidemiological information on 552 patients diagnosed with squamous cell carcinoma of the mouth and oropharynx, treated at Department of Head and Neck Surgery and ENT at Hospital Heliópolis, Hosphel, São Paulo, from 2000 to 2004. It was approved under the number 541 by the Ethics Committee in Research of the Hospital Heliópolis on June 12th, 2007. Records of patients consisted of the following data: name, process code, gender, age, ethnics, alcohol use, smoking habits, place of lesion, TNM classification (which categorizes primary tumor - T, lymphonodal metastasization - N, and distant tumor - M) and follow-up.

According to variables of the study: age was standardized in full year of age; gender (male and female); ethnics (Caucasian, black, brown and yellow Asian skin) and habits (alcohol and smoking). Regarding alcohol and smoke consumption, there were "yes/no" questions. Regarding the amount of consumption, it was scaled: (+) more than 10 cigars with filter/day or two cigars with no filter/day; (++) more than 20 cigars with filter/day or four cigars with no filter/day; (+++) more than 30 cigars with filter/day or six cigars with no filter/day and (++++) more than 40 cigars with filter/day or more than six cigars with no filter/day. Regarding alcohol, (+) consume a dose/day for distilled drinks or half carafe/day for fermented ones; (++) consume two doses/day for distilled drinks or one carafe/day for fermented ones; (+++) consume three doses/day for distilled drinks or 1 ½ carafe/day for fermented ones and, (++++) consume four doses/day or more for distilled drinks or two carafes/day for fermented ones. Regarding place, it was observed oral cavity and oropharynx. Staging followed TNM2 classification. In relation to follow-up, patients were classified as alive without being affect by the disease, alive affected by it, dead from a different reason and dead from the disease. Statistics was observed through tables linked to distribution of nominal variables (gender, ethnics, risk factors, place of lesion, follow-up and year of diagnosing) or numbers (age, time of smoking and drinking habits in absolute-relative frequencies and measures of central and dispersion tendency, according to year of diagnosis and period (gathering in initial period (I and II and advanced III and IV). It was used a Qui-square test for the statistical inference (hypothesis test) of the non-parametric nominal variables distributed in association tables. For the continuous numerical variables, comparison was made with parametric tests according to the possibilities of event of independent variable - Student´s-t non-paired test for the period distribution (bivariate analysis) and analysis of one-step variation (one way ANOVA) for the distribution of diagnosis year (multivariate analysis). In the association tables the statistical significance was described with an asterisk followed by the presentation of the value of the associated probability to the event (p). The cases with no statistical significance were signed with 'NS'. In all cases of analysis, it was chosen a alpha error below 5% (p<0.005) for the rejection of voided hypothesis.


RESULTS

According to Table 1, in relation to gender, male prevailed (456 cases) over female (95 cases), establishing a 5:1 ratio. In the quinquennium, the male incidence remains with no expressive alteration, varying from 79.2% to 89.2%. Regarding females, in the same period, there was a quite expressive percentage varying from 10.8% to 20.8%. However, there was no significant statistical variations, though it was noticed a light tendency for the increase on female cases comparing to the beginning of the researched period.




Regarding ethnics, there was predominance on Caucasians, with 75.3% in relation to Black ones with 14.7%, Brown ones with 9.3% and Yellow ones with 0.7%, adding up 551 cases, presenting a 3:1 ratio. Such variations remained the stable during the period of the analysis.

Regarding risk factors, association between smoking and drinking habits is very expressive on mouth and oropharynx cancer (values can vary from 77.1% to 83.9% per year), adding up 443 patients (80.3%) of all patients studied in this association. Once, the isolated use of alcohol and tobacco (1.4% and 10.3%) was not so expressive, as well as not making use of those limited to 8%, which was not statistically significant.

Regarding the place of lesion, there was a neat predominance on the floor of the mouth, adding up 317 patients (57.5%), followed by oropharynx adding up 140 patients (25.3%), then palate and lips adding up 11 cases and (6.5%) for both. The initial diagnosis place was not significant.

Regarding the follow-up, there were 220 patients who died from cancer (40%), follow-up missing occurred for 185 (33.6%). In the end, 405 patients died (73.3%), 90 of them are still alive (16.3%) and 50 ones (9%) are alive but with the disease. It can be considered that 140 patients (25.5%) belong to the alive-patient group, and 90 out of them are asymptomatic, what can confirm that 25.5% of patients survived to the therapy procedures.

Regarding smoking and alcohol habits, the average time of usage was 56 ± 13 years for former and 34 ± 13 for latter, with no either year-change or behavior observations during the average time of usage regarding carcinogens consumption.

When the same variables for initial (I and II) and advanced (III and IV) periods are considered, the facts repeat themselves, and no variations on age, tobacco and drinking which might alter their values at the beginning and end of the disease occur (Table 2).




In relation to variables distribution, regarding staging, initial (I and II) and advanced (III and IV), one of the distribution allows comparison between a light tendency to increase initial cases at the end of the 5-year period in relation to the beginning and a light decrease of advanced cases in the same period (Table 3).




Regarding gender, there was a more balanced distribution on early diagnosis succeeding instability on advanced cases.

In the initial periods the gender relation (male / female) was 3:1 ratio and in advanced periods was 5:1. Regarding ethnics in initial periods, distribution shows a predominance of Caucasians in relation to the others, what is repeated in the advanced stages of the disease. Regarding risk factors, alcohol and smoking association is expressive in the advanced periods (III and IV) in relation to the initial ones (I and II). This can explain that the association of carcinogens is obvious in advanced stages of the disease, and an expressive statistical significance.

Regarding place of lesion, the predominance of diagnosis in advanced stages is clear except for lip tumor, where diagnosis is done earlier, (75% for stages I and II and 25% for II and IV). This distribution is statistically significant (p=0.001).


DISCUSSION

Among all epidemiological aspects of mouth and oropharynx cancer, there is predominance on males in a 5:1 ratio, according to literature(3-9). Therefore, the increase of it on females with higher consumption of carcinogens has been observed in the last decades(10-12).

Regarding ethnics, there is predominance of Caucasians over the other in a 3:1 ratio. This proportion has been the same in other groups in Brazil(5,10). Black and yellow skin patients are less affected by oral cancer in this study for different reason. Whereas black skin patients suffer from racism and do not have access to preventive programs, the yellow ones, for genetic reasons, are less affected by mouth and orpharyns cancer(5,6,9,10).

Regarding risk factors, the association between tobacco and alcohol is predominant, which is confirmed in three quarters of patients(3,13-16). The isolated chemical dependence is less frequent when alcohol or tobacco is isolated used. Thus, the use of those is normally associated and rarely in a isolated way(3,15).

There is predominance in clinical periods III and IV, though in initial periods I and II, diagnosis figure is low. Although programs of early detection of mouth and oropharynx cancer are a worry for doctors, the delay in diagnosing is common(11,17-21).

The number of patients who do not extend follow-up is large, once they search for specialized centers and, after the treatment, move residence or return to the previous one. 33% of missing patients in the first year of follow-up were considered dead from cancer and analyzed in group with a diagnosis of recurrence and death, according to literature(6,10,12,22,23).

Regarding age, in the fifth decade is more likely to occur. For consumption time of tobacco and alcohol, the average age is over 30. This happens in different types countries even with different habits from Brazil, such as India, where patients consume betel and tobacco(3,5,13,15).

As to the relation between cancer staging and habits for both stages I - II and III - IV, consumption rates of those are constant, which confirms that such relation are not direct connected (advance of disease versus carcinogens quantity)(3,7,13,15,18).

At last, if variables of study are correlated according to the advance of the neoplasm, one can establish constant frequencies during the five years of analysis, which affirms that the incidence of mouth and oropharynx cancer is steady during analysis period (p=0.003) according to literature(6,9,19,20,24). Such period of distribution uniformity was also certified in the analysis of demographic variables (gender and ethnics)(3,5,6,8,18).

However, when analyzing risk factors (alcohol and tobacco), place of lesion and follow-up, one might affirm that the consumption of carcinogens, placing in the floor of the mouth and follow-up are expressive causes (p=0.001) of reserved prognosis of these malignant neoplasm, where local recurrences determine reserved prognosis of the disease(4, 12,13, 17,19,20,23-25).


CONCLUSION

One can conclude that: (1) squamous cell carcinoma of the mouth and oropharynx occurs mainly in males over females in a 5:1 ratio; (2) alcohol and tobacco are habits associated to squamous cell carcinoma of the mouth and oropharynx; (3) death from squamous cell carcinoma of the mouth and oropharynx is associated to disease recurrence and follow-up missing; (4) predominant finding of the advanced periods III and IV limited squamous cell carcinoma of the mouth and oropharynx prognosis.


REFERENCES

1. INCA. Brasil. Ministério da Saúde. Instituto Nacional de Câncer - INCA, Estimativas da incidência e mortalidade por câncer. Rio de Janeiro: INCA; 2004. pp.83.

2. Sobin LH. TNM Classificação dos tumores malignos/Ministério da Saúde, Secretaria de Assistência à Saúde, Instituto Nacional de Câncer. 5ª edição. Rio de Janeiro: Coordenação de Programas de Controle de Câncer; 1997.pp.235.

3. Johnston WD, Ballantyne AJ. Prognostic effect of tobacco and alcohol use in patients with oral tongue cancer. Am J Surg. 1977;134(4):444-7.

4. Brown B, Barnes L, Mazariegos J, Taylor F, Johnson J, Wagner RL. Prognostic factors in mobile tongue and floor of mouth carcinoma. Cancer. 1989;64(6):1195-202.

5. Herter NT, Stahlschmidt R, Bruno L. Câncer de boca. Rev Med S Casa Porto Alegre. 2000;11(18):1909-10.

6. Wünsch-Filho V. The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol. 2002;38(8):737-46.

7. Pimenta Amaral TM, Da Silva Freire AR, Carvalho AL, Pinto CA, Kowalski LP. Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncol. 2004;40(8):780-6.

8. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tomoyose T, Tanaka T, Fukuyama H, Takahashi T. The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. J Oral Pathol Med. 2005;34(6):329-33.

9. Choi KK, Kim MJ, Yun PY, Lee JH, Moon HS, Lee TR, Myoung H. Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults. Oral Oncol. 2006;42(2):208-17.

10. Berto JC, Rapoport A, Carlos LN, Cestari Filho GA, Javaroni AC. Relação entre o estadiamento, o tratamento e a sobrevida no câncer de faringe. Rev Col Bras Cir. 2006;33(4):207-210.

11. Iro H, Waldfahrer F. Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients. Cancer. 1998;83(10):2201-7.

12. Urist MM, OBrien CJ, Soong SJ, Visscher DW, Maddox WA. Squamous cell carcinoma of the buccal mucosa: analysis of prognostic factors. Am J Surg. 1987;154(4):411-4.

13. Bundgaard T, Bentzen SM, Wildt J. The prognostic effect of tobacco and alcohol consumption in intra-oral squamous cell carcinoma. Eur J Cancer B Oral Oncol. 1994;30B(5):323- 8.

14. Muñoz Herrera A, Santa Cruz Ruiz S, Fonseca Sánchez E, Nieto Palacios A, Blanco Pérez P, Gómez González JL. [Survival rate in epidermoid carcinoma of the oral cavity] Supervivencia en el carcinoma epidermoide de cavidad oral. Acta Otorrinolaringol Esp. 2001;52(5):381-6.

15. Garzino-Demo P, DellAcqua A, Dalmasso P, Fasolis M, La Terra Maggiore GM, Ramieri G, Berrone S, Rampino M, Schena M. Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma. J Craniomaxillofac Surg. 2006;34(6):344-50.

16. Dedivitis RA, França CM, Mafra ACB, Guimarães FT, Guimarães AV. Características clínico-epidemiológicas no carcinoma espinocelular de boca e orofaringe / Clinic and epidemiologic characteristics in the with squamous cell carcinoma of the mouth and oropharynx. Rev Bras Otorrinolaringol. 2004;70(1):35-40.

17. Evans SJ, Langdon JD, Rapidis AD, Johnson NW. Prognostic significance of STNMP and velocity of tumor growth in oral cancer. Cancer. 1982;49(4):773-6.

18. Rich AM, Radden BG. Prognostic indicators for oral squamous cell carcinoma: a comparison between the TNM and STNMP systems. Br J Oral Maxillofac Surg. 1984;22(1):30-6.

19. Fang FM, Leung SW, Huang CC, Liu YT, Wang CJ, Chen HC, Sun LM, Huang DT. Combined-modality therapy for squamous carcinoma of the buccal mucosa: treatment results and prognostic factors. Head Neck. 1997;19(6):506-12.

20. Gluckman JL, Pavelic ZP, Welkoborsky HJ, Mann W, Stambrook P, Gleich L, Wilson K, Righi P, Portugal LG, McDonald J, Biddinger P, Steward D, Gartside P. Prognostic indicators for squamous cell carcinoma of the oral cavity: a clinicopathologic correlation. Laryngoscope. 1997;107(9): 1239-44.

21. Dantas DD, Ramos CC, Costa AL, Souza LB, Pinto LP. Clinical-pathological parameters in squamous cell carcinoma of the tongue. Braz Dent J. 2003;14(1):22-5.

22. El-Husseiny G, Kandil A, Jamshed A, Khafaga Y, Saleem M, Allam A, Al-Rajhi N, Al-Amro A, Rostom AY, Abuzeid M, Otieschan A, Flores AD. Squamous cell carcinoma of the oral tongue: an analysis of prognostic factors. Br J Oral Maxillofac Surg. 2000;38(3):193-9.

23. Sasaki T, Moles DR, Imai Y, Speight PM. Clinicopathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age. J Oral Pathol Med. 2005;34(3):129-33.

24. Jones KR, Lodge-Rigal RD, Reddick RL, Tudor GE, Shockley WW. Prognostic factors in the recurrence of stage I and II squamous cell cancer of the oral cavity. Arch Otolaryngol Head Neck Surg. 1992;118(5):483-5.

25. Jones AS. Prognosis in mouth cancer: tumour factors. Eur J Cancer B Oral Oncol. 1994;30B(1):8-15.








1. Master degree student of Science of Health at Hospital Heliópolis, HOSPEHEL, São Paulo (sponsored by MEC/CAPES).
2. PhD in ENT and Head and Neck surgery by Universidade Federal de São Paulo - Escola Paulista de Medicina (Federal University) - Professor of ENT and Head and Neck surgery at Universidade Metropolitana de Santos.
3. Teacher at the Department of Surgery at Faculdade de Medicina da Universidade de São Paulo (FMUSP) - Coordenator of the Post-graduation course in Science of Health at Hospital Heliópolis, HOSPEHEL, São Paulo.
4. PhD in Medicine and Endocrinologia by Universidade Federal de São Paulo - Escola Paulista de Medicina (Federal University) - Teacher of the post-graduation course in Science of Health at Hospital Heliópolis, HOSPEHEL, São Paulo.
5. PhD in ENT and Head and Neck surgery by Universidade Federal de São Paulo - Escola Paulista de Medicina (Federal University) - Professor of the Post-graduation course in Science of Health at Hospital Heliópolis, HOSPEHEL, São Paulo.

Curso de Pós-Graduação em Ciências da Saúde - Hospital Heliópolis, São Paulo. (Post-Graduation Course in Science of Health)

Rogério A. Dedivitis
Address: Rua Cônego Xavier, 276 - São Paulo/SP - CEP: 04231-030 - Fax (11) 2273-8224 - E-mail: hosphel.cpg@terra.com.br

This article was submitted to SGP (Sistema de Gestão de Publicações - Publication Management system) of R@IO on May 6th, 2007 and approved on September 9th,2007 at 12:51:49.

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