Introduction: Castleman\'s disease is a lymphoproliferative benign rare disorder that most often presents as mediastinal adenopathy, but can affect head and neck region as a cervical adenopathy of unknown etiology. Objective: We present a case of this rare disease affecting cervical region to remember this hypotesis as a differential diagnosis of cervical adenophaty, although the most common is the thoracic disorder. Case report: A 27-year-old male patient, with clinical history of a cervical mass for seven months, evaluating with progressive and painless growth. Conclusion: With this case report we underline the clinical significance of this pathology for the differential diagnostic of cervical adenopathies for accurate diagnosis and treatment approach.