OBJECTIVES: To describe a patient with rhinosinusal mucormycosis and literature review. Clinical case: male patient, 24 years old, suffering from acute lymphoblastic leukemia undergoing chemotherapy at regular frame of 7 days of development of nasal obstruction, purulent rhinorrhea unilateral left over both anterior and posterior and occasional fever peaks since the beginning frame; for rhinoscopy observed purulent rhinorrhea in moderate quantity in FNI, is made up endoscopic finding described above that found at the middle left middle necrotic tissue and also designed the same; TAC nose and paranasal sinuses: left maxillary and ethmoid opacification, remaining free of the paranasal sinuses, endoscopic drainage is done the same with good development and remarkable improvement in the sinus, also with hematologic improvement without recurrence in postoperative controls. CONCLUSION: Mucormycosis rhinosinusal is characteristic of immunocompromised patients, antifungal treatment should be instituted as soon as possible, surgery eliminates the infection, the most widely used technique in uncomplicated cases as described endoscopic surgery, both must be accompanied by a good stabilization of the hematologic patients, observing a good development in the face of a correct treatment surgical clinical.