Introduction: Gastro-esophageal reflux (GER) is a complex pathology characterized by many clinical symptoms: gastroenterological and odontostomatological, pneumological and otorhinolaryngological. The association between gastroesophageal reflux disease and laryngeal disorders in adults is well established. Objective: The aim of the study was to evaluate the association between dysphonia and gastroesophageal reflux. Methods: 36 patients (11 males and 25 females) aged between 32 and 78 years (average: 61 years), positive for a GER history, were enrolled in the study. Before and after the treatment, each patient was assessed by videolaryngostroboscopy, ENT examination, fibrolaryngoscopy and blood test for evaluation of Helicobacter Pylori (H.P). The patients were asked to indicate, for every check-up, the subjective entity of their symptoms by a numeric reference scale. Patients have been treated with omeprazole, specific diet and opportune hygienic sanitary precautions for 4 weeks. Patients positive to H.P. underwent a radical treatment associated with clarithromycin. Results: Using a laryngeal grading system, we discovered an objective improvement, confirmed by the average score obtained from the subjective evaluation scale. Conclusions: In patients with dysphonia associated with GER, an analysis with videolaryngostroboscopy and evaluation of the vocal spectrography can help to evaluate the effectiveness of the therapy.