Nasopharyngeal carcinoma is usually an insidious rout of clinical disease manifestations and nonspecific in the early stages, so it is difficult to establish a diagnosis early. The most common presenting symptoms are the ontological type (serous medium otitis) and cervical adenopathy. Presents a case of Gradenigo syndrome due to tumor extension to the base of the skull. Patient 29-year-old deaf-mute who was consulted by othorrea more pain in his right ear with 8 months of development on several occasions treated by doctors as infectious. It was aggregated syndrome vertigo, facial pain, paralysis and paresis of the VII via the pair that refers to our service. The neurological recovery compatible with Gradenigo syndrome combined with unaffected couples rights craneal V and VI. Also there is engagement of pairs VII, IX and XI. It was realized recovery took place and found the existence of striking lesion occupying the entire external auditory pathway, was a squamous cell carcinoma moderately differentiated. A magnetic resonancecranial demonstrated the extent of tumor FELIZ the base of the skull and seiocavernous right. It was indicated radiotherapeutic treatment plus chemotherapy. It is a very interesting case for the complexity of it.