OBJECTIVES: The hypogammaglobulinemia is a change in humoral immunity characterized by decreased serum levels of antibodies, found in several primary immunodeficiency syndromes. It usually affects men and women equally. The most important clinical aspect is the predisposition to recurrent infections of the respiratory tract, mainly by encapsulated bacteria. Moreover, there is increased incidence of chronic diarrhea, cancer and autoimmune diseases. It is aimed at reporting a case of hypogammaglobulinemia associated with recurrent sinopulmonary infections in a patient treated at the Service of Otolaryngology, Federal Hospital of the Bonsucesso. CASE REPORT: Female patient, 34 years old, white, presenting, since adolescence, recurrent respiratory infections and under intermittent diarrhea and vomiting. Initiated this multidisciplinary service due to worsening of sinopulmonary. The computerized tomography of the chest and paranasal sinuses demonstrated bilateral bronchiectasis and pansinusitis. Biopsy of the maxillary sinus for diagnostic investigation showed nonspecific positive culture for seed and encapsulated. In cases of suspected immunologic disease due to bronchopulmonary framework, the laboratory evaluation identified hypogammaglobulinemia. Currently, in use of intravenous immunoglobulin every 4 weeks irregularly. Returns today with a complaint to the service being started nasosinusal important oral antibiotic (amoxicillin clavulanate) and topical nasal corticosteroids (fluticasone), besides, an outpatient. CONCLUSION: We highlight the need for clinical diagnosis and investigation of immunodeficiency before a patient not responding to adequate treatment of rhinosinusitis, especially when accompanied by pulmonary symptoms.