OBJECTIVE: To describe the case of neurological symptoms mucopyoceles CASE REPORT: RAJR, 31 years old, female, presented headache character holocraneal pulsatile, with progressive worsening, refractory to opioid plus bilateral scotoma and eye pain for 10 days. It was performed endonasal surgery for polyposis nasosinusal 4 years with persistence of nasal crusts and fetid discharge from the end of the procedure. The endoscopy revealed the presence of green thick discharge with a large amount of crust hardened and adhered to, with areas of green shield on the topography of the middle meatus and middle turbinate right. The CT showed a solid background hyper attenuating expansive, poorly demarcated contours, located in the posterior ethmoid cells, providing thinning of the bone walls of the ethmoid cells and cribriform crest, with erosion of the super-medial wall of the right orbit and involvement of the extraconal medial, suggestive of mucoceles. We performed another endoscopic surgery with opening and expansion of the ethmoid sinus showing output of purulent material in the region, confirming the diagnosis of mucopyoceles. CONCLUSION: The mucoceles are benign lesions with expansive character that can cause serious complications at orbital and intracranial and, therefore, must be diagnosed and treated early. Typically, pain occurs when secondary infection becoming mucopyoceles. Functional endoscopic sinus surgery is an excellent means of access for the treatment of mucoceles.