OBJECTIVE: To report the case of a patient with a lesion in tonsils was confirmed the presence of HPV (Human Papillome Virus). CASE REPORT: OHSM, 27 years old, male, married, was treated at St. Francisco Hospital, complaining of pain in throat intense, continuous, three months, without fever, with partial improvement in symptoms. It was reported dysphagia to solids. He started snoring and sleep apnea in those. He denied: otological complaints / audiological / nasal, alcohol and tobacco; base pathologies / drug use continued. Physical Examination: grade III bilateral tonsillary hypertrophy, with multiple pediculated lesions on its surface. Fibronasopharyngolaryngoscopy (FNL): cavum free projections tonsil pharyngeal subsequently reducing the light. VDRL - not reactive anti-HIV: No reagent Patient underwent bilateral tonsillectomy material was sent to pathology and hybrid capture. Macroscopic Diagnosis - two white-brownish mass, measuring 3.5 x3, 0 cm and 4.0 x3, 5 cm. The sections are solid and smooth. Diagnosis-Microscopic hyperplasia of lymphoid follicles, little neutrophil and hyaline material within the crypts. In between there is edema and hyperemia anatomo-pathological diagnosis: acute chronic tonsillitis Hybrid capture HPV: A and B Positive CONCLUSION: Presence of DNA-HPV testing for the viruses of groups A and B. CONCLUSION: In the face of atypical lesions in the oropharyngeal cavity search must be made for the presence of HPV, highlighting the importance of hybrid capture.