Report a case of nasal tuberculosis isolated. MCP, 83 years old, female, was looking for the Otolaryngology Service in 2008 for nasal injury. As a complaint, she referred only itchy lesion that was located in the intra nasal septum and columella. Rhinoscopy and nasal endoscopy showed total destruction of the septum to open nasal cavity, presence of crusts and secretion in the nasal cavities. Oroscopy and otoscopy unchanged. Asked for syphilis serology, Paracoccidioidomycosis and C-ANCA, all negative. The Computed tomography and chest radiography showed no abnormalities suggestive of tuberculosis. Biopsy performed which showed lesions compatible with nasal tuberculosis. Started treatment with regimen I (2RH/4RH - Ministry of Health) for 6 months, with apparent resolution of the case. In January of 2011 he returned with lesions of similar appearance to the past, performed another biopsy showed the presence of bacilli and pathological again compatible with nasal tuberculosis. Held a new treatment regimen III (3SZEEt/9EEt - Ministry of Health) for 12 months, the recommended therapeutic failure in treatment with regimen I. One month after completion of treatment, returned to the clinic with nasal impetigo at the site previously affected by tuberculosis, a new biopsy was negative for tuberculosis. Tuberculosis of the nose is a rare manifestation, with few cases described, presenting diagnostic difficulty, requiring research laboratory and anatomic pathology for confirmation, and many patients remain long periods without an accurate diagnosis, so it is prudent to otolaryngologists maintain that they are aware of this infection as a potential cause of a common lesion in head and neck.