The sinonasal non-Hodgkin lymphoma is a rare malignancy, accounting for 0.17% to 2% of all non-Hodgkin lymphomas. Two factors are important for the prognosis: the stage of disease and paranasal extension. In addition, nasal lymphomas with histological type T have a worse prognosis than the type B. OBJECTIVE: We report a case of non-Hodgkin lymphoma diffuse large cell that affects the sinuses with erosion of the papyraceous lamina and the floor of the anterior tank. Methods: Male patient, 76 years, diagnosed with left sinus tumor underwent endoscopic technique for tumor resection with centripetal block. After surgery and the diagnosis the patient was referred for cancer treatment with chemotherapy. RESULTS: Despite the intra-orbital invasion and intra-cranial, there was complete tumor resection and reconstruction of the floor of the left anterior tank. There were no signs of tumor recurrence after 12 months of treatment. CONCLUSION: The endoscopic surgery centripetal chemotherapy-associated postoperative shown to be a safe and feasible for treating non-Hodgkin's lymphoma.