OBJECTIVE: To report a patient with amniotic band syndrome presenting craniofacial abnormalities, with important implications for functional. CASE REPORT: The patient is a child of 1 year and 3 months old, the fourth child of a couple of non-consanguineous parents and no family history of similar defects. The mother had 43 years old and the father 42 years old. The child was born by cesarean section for premature rupture of membranes at term, weighing 2120 g, measuring 46 cm and Apgar scores of 9 in the fifth minute. The pregnancy was uneventful. The mother denies the use of tobacco, alcohol or other teratogenic agents during pregnancy. At birth we identified the presence of craniofacial abnormalities and upper limbs. These include eyelid agenesis, craniofacial asymmetry, an important strengthening bilateral external mark of constriction involving face, abnormalities of the upper lip shape (resembling a sketch of cleft lip), constriction at the distal end of the fourth finger of left hand and right hand radial deviation with shortening of the ipsilateral forearm. Evolved with developmental delay. CONCLUSION: The sum of the patient's clinical findings led to the diagnosis of amniotic band syndrome. The craniofacial abnormalities are quite variable, as observed in our patient. The importance of speech therapy, among other specialties, the evaluation and treatment these patients refers to the existence of changes in speech, language, swallowing and orofacial myology.