OBJECTIVE: To report the case in which platelet rich plasma (PRP) was effective in promoting wound healing and discuss relevant literature. CASE REPORT: F.M.C., a 27-year-old female patient underwent one surgery for acoustic neuroma in the left ear. Three months after the surgery, the patient's left face exhibited palsy. An ulcerated lesion had led to a loss of substance in the left upper and lower lips, and nasal vestibule. Rheumatic diseases and granulomatous findings were investigated and discarded. Treatment with topic steroids was undertaken for a year without success. Owing to the possibility of vascular insufficiency, PRP was suggested. PRP was performed 3 times at intervals of 30 days. After the last application, upper and inferior lip tissue began to regenerate, beyond that required for healing of the nasal vestibule. CONCLUSION: PRP has shown good results in the healing of wounds. Among 50 selected studies that addressed the use of PRP, 80% exhibited positivity; only 6% exhibited negativity. Increased research casuistry was associated with positive results. Twenty-six studies conducted in humans reported 25 positive results (p = 0.001). All cases with cartilage and tendon involvement succeeded. The average concentration of PRP used was 1,056,000 platelets/µL; there was no relationship between concentrations and results.