The first eletrocnic Journal of Otolaryngology in the world
ISSN: 1809-9777

E-ISSN: 1809-4864

 
1917 

Year: 2014  Vol. 18   Num. 4  - Oct/Dec - (15º)
DOI: 10.1055/s-0034-1387163
Section: Case Report
 
Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): A Case Report and Literature Review
Author(s):
Rabindra Bhakta Pradhananga, Kripa Dangol, Anjan Shrestha, Dharma Kanta Baskota
Key words:
sinus histiocytosis - massive lymphadenopathy - Rosai-Dorfman disease
Abstract:

Introduction: Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder of unknown etiology. Usually it presents with massive painless cervical lymph node enlargement. Histologically, it shows proliferation of distinctive histiocytic cells that demonstrate emperipolesis in the background of a mixed inflammatory infiltrates. Immunohistochemically, the cells are positive for markers such as CD68 and S100.

Objective: To report a case of a 12-year-old patient with multiple sites of cervical lymphadenitis, which was diagnosed as RDD histopathologically as well as immunohistologically.

Resumed Report: A 12-year-old girl presented with multiple painless sites of cervical lymphadenitis without any systemic and other ear, nose, and throat manifestations. The biopsy report of the lymph node showed dilatation of the sinuses, filled with histiocytes having foamy cytoplasm. Many of the histiocytes were engulfing mature lymphocytes. The sinus histiocytes were strongly positive for S-100 protein.

Conclusion: RDD must be considered in the differential diagnosis of massive or multiple lymphadenopathies.

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