Objective: To analyze the socioeconomic profile and the main co-morbid of the participants of the Program of Control of Tobaccos of Curitiba between 1999 and 2009. Materials and Methods: Transversal study, of descriptive character, with 839 participants of the Program of Control of entailed Tobaccos of Curitiba to the Basic Units of Health of Saint Felicidade, Listener Pardinho and Jardim Gabineto, in the understood period between 2009 and 1999. It was used, for the analysis of the data, the French software of origin called Sphinx Lexical. Results: The enclosed population in the study was of feminine predominance (62.8%), with 40-49 average years of age, good level of schooling and with familiar income between two and four minimum wages. The com-morbid most prevalent had been psychiatric, being the most frequent depression, followed of the anxiety. The organic illnesses come in according to place, being more common arterial hypertension, followed of gastrointestinal and pulmonary illnesses. The verbal injuries had been less prevalent. Conclusion: The analysis of the socioeconomic profile and the co-morbid of the population of the present study, showed singular characteristics indicating the necessity of a boarding directed in this group. Knowing the population better is possible to elaborate more efficient strategies in the handling of the treatment of ceasing of the tobacco, and when identifying the main co-morbid we obtain to carry through control of damages and focus orientation in the problem, in allowing to act in the trigger factor of the vice and in the difficulties of abandonment of the same.