OBJECTIVE: To describe a patient with nasopharyngeal carcinoma and bibliographic review; CASE REPORT: Male patient 16 years of age coming from Ciudad del Este, Paraguay, who consulted the department of otolaryngology at the Hospital of Clinics, College of Medical Sciences, National University Assumption in November of 2009 with a one year history of development of nasal obstruction on the left with intermittent epistaxis in several opportunities, the latest episode of two days, accompanied by clear rhinorrhea, progressive decrease in olfaction, feverish sensation in various opportunities, Migraine intermittent bilateral hearing loss at three months of development and weight loss of approximately 10 kg in one year. CONCLUSION: For the correct diagnosis of nasopharyngeal carcinoma is essential a high degree of suspicion and a proper assessment. Notwithstanding the laboratory analysis of the Epstein-Barr virus, particularly the plasma DNA of Epstein-Barr virus stock, demonstrated their usefulness for distribution, prognosis and further post-treatment. It would help carry out this study to all patients with diagnosis of nasopharyngeal carcinoma, in this way to establish a distribution more correct and right and bring in the same way, one THERAPY prognosis the basis of each patient, since it is a tumor that affects patients at a time very early in life.