The malignant neoplasm of nasopharynx, corresponding to 2% of malignant tumors of head and neck and 0.25% of all tumors is rare in the world except China and the Asian region. Is characterized by its invasive nature, symptoms and delayed by the difficulty in the examination of the nasopharynx. It presents a female patient 19 years of age without previous pathology basic query frame by 3 months of development, characterized by left ear feeling stuffy and uncomfortable in the throat like an occasional stabbing. Is aggregate nasal obstruction intermittent left nostril, purulent rhinorrhea, epistaxis occasional self-limiting. On physical examination, a normal anterior rhinoscopy, posterior rhinoscopy: vegetative lesion with crusts, which affects the soft palate and uvula. That does not leave to see the Eustachian tube or the left choanae. For oroscopy hemitaste bombment of soft left. It is realized tomography with contrast is performed, where it is observed: tumor imaging with density of soft parts occupying the nasopharynx and oropharynx descends, with little contrast enhancement, without invasion of skull base, prevertebral fascia or great vessels. Realizes recession carries lower endoscopic lesions. Pathology reports: malignant epithelial neoplastic proliferation of high degree, consisting of small cell nuclei. Takes place inmuhistochemistry which states: poorly differentiated squamous cell carcinoma, HPV type (p16 +) before nasopharyngeal type (EBV-). It Refers to a patient for radiotherapy.