OBJECTIVE: case report of nasopharyngeal carcinoma. CASE REPORT: FMS, 37 years old, male, complaining of nasal congestion and dizziness for two years. Sought help from the emergency room in his home town, with purulent rhinorrhea, a greenish and fetid, with improvement after antibiotic use. A year ago, notes that mild epistaxis after blowing your nose, associated with nasal obstruction and rhinorrhea. Six days ago, said a new episode of epistaxis with significant headache hemicranial left. Performed Computerized Tomography of the paranasal sinuses and Magnetic Resonance at the request of the otolaryngologist in your city of origin and was referred to the Felippu Institute of Otolaryngology, due to the presence of mass in the left nasal cavity. The patient underwent total resection of the tumor in the left nasal cavity, held on 3/20/12; the material being sent for anatomopathological, whose diagnosis was carcinoma of nasopharyngeal type no keratinized, differentiated and undifferentiated subtypes. Pathology (3/20/12): The immunohistochemical profile, associated with morphological findings and the positive outcome of the research EBV (Epstein-Barr virus) by in situ hybridization study, is compatible with nasopharyngeal carcinoma no keratinized, different subtypes and undifferentiated. Patient improved postoperatively, followed with Computerized Tomography of the paranasal sinuses and control referred to an oncologist for radiotherapy. CONCLUSION: To determine the surgical indication for malignant neoplasm of the nasopharynx and its resection margins according to the degree of infiltration of adjacent tissues. And establish criteria for adjunctive therapy in the postoperative follow-up.