Introduction: Mucormycosis is a life-threatening fungal infection, commonly with fatal evolution, caused by fungi belonging the order Mucorales, which Rhizopus specie is responsible for 70 % of rhinoorbitocerebral mucormycosis, its most common clinical type. This unfavorable evolution is justified, in part, by a specific characteristic of this fungus: the blood vessels invasion, resulting in thrombosis and ischemic infarctation of the involved tissue. The treatment must be aggressive with Amphotericin B, surgical debridement of necrotic tissues, hiperbaric oxygen therapy and use of granulocyte colony stimulating factor. Aim: Report a case of a patient with rhyno-orbitocerebral mucormycosis with unfavorable evolution. Case report: A 35-year-old female patient with Samter´s Triad, who was submit to long-term corticosteroid therapy to asthma control and developed rhyno-orbitocerebral mucormycosis with fatal evolution. Conclusion: Rhino-orbitocerebral mucormycosis is a serious clinical state that requires an exact diagnosis and a quick treatment, since it still causes a high mortality, both the infection characteristics and the underlying medical condition of the patients.