Introduction: Acute diffuse external otitis is a dermatitis that affects all or part of the external ear canal skin. It is most often caused by the external ear canal ephitelium’s particularities. It is the most common ear disease seen in summer time. There are numerous contributory factors that predispose this disease. Although there are many protective mechanisms, recurrences are often seen among swimmers. Objective: We studied a topical treatment composed of queratoplastic agents associated with a systemic treatment with antibacterial vaccine, for the elimination of the disease. Methods: Twenty-three patients with recurrent external otitis were seen at ENT Division of Hospital das Clínicas of University of São Paulo. All of these patients practice an aquatic sport daily, staying in contact with water for at least two hours a day. The swimmers were treated with the application of queratoplastic topical agents and systemic vaccine buildup of bacterial antigens attenuated toxins. Results: The symptoms most often observed were pruritus, ear pain, hypoacusia and external ear canal secretion. During the clinical examination, we observed skin lesions, secretion, debris and cerumen, skin edema in the ear canal, and epidermal thickening or thinning. The results of the clinical evaluation demonstrated that the treatment employing topical queratoplastic agents and antibacterial vaccines was effective in preventing, as well as suppressing, the disease process. Reinfection was not observed. Conclusão: The association of queratoplastic agents and systemic vaccine for the treatment of diffuse external otitis in swimmers was efficient and easy to use.